When polio vaccine backfired tainted batches killed 10 and. Recent innovations in tumour exome sequencing have signalled the new era of. Currently, there are several fda approved cancer nanomedicines, such as abraxane, doxil, oncaspar, etc. Professor mark kendall, an inaugural arc future fellow at the university of. Mark kendall aims to shake up how vaccines are delivered with the nanopatch. Nanopatch polio vaccine success uq news the university.
Her efforts so far have proven successful, also thanks to the development of a stateoftheart model of human skin that her team uses to finetune the bodys reaction to different. There she worked on a variety of vaccinology and immunology projects, with a focus the investigation of mechanisms underlying the improvements in immunogenicity. A needlefree vaccine patch thats safer and way cheaper. Anne gottsdanker was a chipper 5yearold santa barbara girl 50 years ago, when her family doctor gave her one of the first of the newly approved salk polio shots. Jan 10, 20 when it comes to protecting millions of people from deadly infectious diseases, mark kendall thinks a fingertipsized patch covered in thousands of vaccine coated microscopic spikes is the future. I want to make a difference and to be remembered as. It targets the abundant immune cell populations in the skins outer layers, rather than muscle, resulting in a more efficient vaccine delivery system, professor kendall said.
Nanopatch technology developed by professor mark kendall could have a global impact by improving vaccines so they no longer have to be. Usually, a dead or weakened version of the diseasecausing germ bacteria or virus is introduced to our immune system. Aug 30, 2012 prof mark kendall the nanopatch presents the possibility of just using a fraction of the dose compared to the needle and syringe and weve proven that in the mouse model and we seek to, to prove. He is recognised as coinventor of the technology enabling the hpv vaccines, currently used.
To be a center of outstanding basic immunology research, highly respected for conducting innovative and rigorous research that leads to major discoveries into the mechanisms of immunity. Mark kendalls nanopatch could revolutionize infectious disease protection for milions globally. Biomedical engineer mark kendall demos the nanopatch, a onecentimeterbyonecentimeter square vaccine that can be applied painlessly to the skin. Kendall hopes to produce vaccines that cost 50 cents per dose. Oct 09, 2012 the nanopatch, developed by university of queensland professor mark kendall and his bioengineering and nanotechnology team, uses 100 times less vaccine than a syringe and is smaller than a postage. Kendall says one key limitation of needle and syringe vaccines, beside needing expensive coldchains and specialist staff to deliver them, is that the needle puts the vaccine into muscle, which. He shows how this tiny piece of silicon can overcome four major shortcomings of the modern needle and syringe. In an experiment with a canadian company, they showed you could actually identify a new strain of virus and produce a candidate vaccine in three to four weeks. Professor kendall said the nanopatch has been tested for every class of vaccine including influenza, malaria and cervical cancer. As a professor at the university of queensland, he leads a research group working at tri in brisbane, australia on the immunobiology of epithelial cancers. Professor mark kendall, a university of queensland researcher who invented the nanopatch a needlefree vaccine delivery device has. His team has partnered with the world health organisation to run a.
So far, kendalls research team at the university of queenslands institute for biotechnology and nanotechnology have tested the nanopatch on mice using various inoculations including against flu, the human papillomavirus hpv that causes cervical cancer, and even with a potential new vaccine against mosquitoborne viral disease chikungunya. In 2015, kendalls team, in collaboration with the world health organization who and the us centres for disease control and prevention, tested an inactivated poliovirus vaccine on rats using the nanopatch. Nanopatch is a small square of silicon that sticks on the skin like a postage stamp and delivers vaccine directly to the bodys immune system. Vaccine technology earns honour for australian mark kendall. We compared the nanopatch to the traditional needle and syringe, and found that there is about a 40fold improvement in delivered dosesparing, professor kendall said. Improving the reach of vaccines to lowresource regions. Upon nanopatch application, silicon microprojections coated with vaccine deliver their payload directly into the vicinity of a network of skin antigenpresenting cells. The nanopatch is a device on the edge of the classification of microneedle devices, employing microneedles that are smaller and more densely packed than other patches, which have been defined as projections. While this may seem like a miracle for anyone with a fear of needles, it may do more for poorer countries. Aibns prof mark kendall is the inventor of the nanopatch, a needlefree vaccine delivery device which is under rapid research and development to product through spinout company vaxxas. Prof mark kendall from the australian institute for bioengineering and nanotechnology aibn presents a talk on his vaccine delivery device, the nanopatch at ted global 20.
The nanopatch presents the possibility of just using a fraction of the dose compared to the needle and syringe and weve proven that in the mouse model and we seek to, to prove that in, in humans. Oct 05, 2017 efforts to rid the world of polio have taken another significant step. The nanopatch technology aims to provide an optimized, differentiated needlefree vaccine delivery solution that safely and cost effectively amplifies. Nov 05, 2015 view mark kendalls profile on linkedin, the worlds largest professional community. Kendalls research in animals shows that a 450 ng dose of an influenza vaccine was far more effective delivered through the patch than 600 ng of the same vaccine delivered via a needle. In some cases, inactivated toxins produced by the germ are used in the vaccine to develop immunity for example, diphtheria and tetanus vaccines. Professor mark kendall was all set for a career in aerodynamics when. Npbased therapeutics are emerging as a noteworthy field in clinical research. Uq technology with the power to revolutionise global vaccine delivery. Vaxxas is a company working to improve current vaccines and create the next generation of immunizations.
Improving the reach of vaccines to lowresource regions, with. Nanopatch is the vaccine delivery system for people who. It uses thousands of vaccine coated pins that perforate into the skin. The university of queenslands australian institute for bioengineering and nanotechnology aibn is an integrated multidisciplinary research institute bringing together the skills of worldclass researchers in the areas of bioengineering and nanotechnology. Oct 05, 2017 a fresh study of the nanopatch a microscopic vaccine delivery platform first developed by uq researchers has shown the device more effectively combats poliovirus than needles and syringes. We found, after vaccinating mice, that antiinfluenza igg antibody and haemagglutinin inhibition assay titre response induced by the nanopatch with delivered dose of 6. Professor ian frazer is a clinician scientist, trained as a clinical immunologist in scotland. A fresh study of the nanopatch a microscopic vaccine delivery platform first developed by uq researchers has shown the device more effectively combats poliovirus than needles and syringes. Nanopatch tipped to replace syringe the sydney morning herald. Needleless vaccines one step closer with nanopatch.
A vaccine is a biological preparation that provides active acquired immunity to a particular disease. Patch inventor professor mark kendall said the study exhibited a key advantage of the nanopatch. Nanopatch is the vaccine delivery system for people who fear. Professor paul young school of chemistry and molecular. Recognition for vaccine delivery using rocket science professor mark kendall from the university of queensland has been awarded the 2016 csl young florey medal, for his work on the nanopatch, a needlefree vaccine delivery device which applies the aerodynamic principles more commonly found in rockets to a medical application. Now the professor is working with vaxxas and the schools institute for bio engineering and nanotechnology to get the patch ready for the public. Jan 19, 2014 prof mark kendall from the australian institute for bioengineering and nanotechnology aibn presents a talk on his vaccine delivery device, the nanopatch at ted global 20.
Dry, needlefree vaccines exist and are saving lives. Microdevice use for vaccination has grown in the past decade, with the promise of easeofuse, painless application, stable solid formulations and greater immune response generation. The nanopatch was designed with these desirables in mind, with the aim of circumventing current logistical challenges presented by needle delivery of liquid vaccine. See the complete profile on linkedin and discover marks connections and jobs at similar companies. A vaccine typically contains an agent that resembles a diseasecausing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The nextgeneration vaccine delivery system, created by vaxxas, is called the nanopatch and is the size of an adult thumbnail. Nanopatch tipped to replace syringe the sydney morning. Earlier this year, vaxxas, along with kendalls research team at the university of queenslands australian institute for bioengineering and nanotechnology and the who, tested an inactivated. Apr 25, 2005 anne gottsdanker was a chipper 5yearold santa barbara girl 50 years ago, when her family doctor gave her one of the first of the newly approved salk polio shots. Recognition for vaccine delivery using rocket science. Kendall s work drew the attention of the cdc and the world health organization.
Bioengineer developing needlefree nanopatch vaccines. Vaccines are clever, they trick our bodies into building immunity against infectious diseases, without causing the illness. A simple, easytoadminister polio nanopatch vaccine could increase the availability of the ipv. Looking a bit like a fuzzy computer chip, the nanopatch uses tiny powdercoated spikes to deliver a small dose of vaccine just under the skin, immunizing a person in about a minute. Nanopatch microprojections breach the stratum corneum and penetrate into the viable epidermis and dermis.
Professor kendall s method of vaccine delivery has important advantages compared to traditional syringesit is painless, requires a fraction of the dose, and does not need refrigeration during transportation and storage. Targeted delivery of candidate dengue virus subunit vaccine to the skin using the nanopatch. Designer vaccine nanodiscs for personalized cancer. Because the nanopatch is costeffective, it would be easier to access in impoverished areas. Australian institute for bioengineering and nanotechnology. It targets the abundant immune cell populations in the skins outer layers, rather than muscle. Microdevice use for vaccination has grown in the past decade, with the promise of easeofuse, painless application, stable solid formulations. Michelle mcintosh awarded dr john dixon hughes medal for. Despite the tremendous potential of peptidebased cancer vaccines, their efficacy has been limited in humans. The nanopatch works similarly to a nicotine patch, administering vaccine for skin absorption directly to areas where immune cells are most abundant, rather than the lesseffective method of. Professor kendall said the nanopatch had been used to administer an inactivated type 2 poliovirus vaccine in a rat model.
Jan 11, 20 so far, kendall s research team at the university of queenslands institute for biotechnology and nanotechnology have tested the nanopatch on mice using various inoculations including against flu, the human papillomavirus hpv that causes cervical cancer, and even with a potential new vaccine against mosquitoborne viral disease chikungunya. The nanopatch works similarly to a nicotine patch, administering vaccine for skin absorption directly to. Nanopatch professor mark kendall is a worldleading innovator in producing technology solutions to global health problems. Jun, 20 image caption prof kendall has set up a company to commercialise the nanopatch the projections on the nanopatch work with the skins immune system. A fresh study of the nanopatch a microscopic vaccine delivery platform has shown the device more effectively combats. Each nanopatch consists of a 16 mm 2 silicon base with 3364 microprojections 21, 025 cm. Biomedical engineer mark kendalls innovative nanopatch could. Mark kendall wins csl young florey medal with nanopatch vaccine.
If less vaccine is needed per person, more individuals can be vaccinated. Needleless technology partners with merck newscomau. Nanopatchrevolutionising treatment of disease across the. Professor kendall started mapping the skins immune system, inventing the nanopatch that delivers vaccines by targeting immunerich cells in the. Vaccines protect vulnerable people in our community such as very young children, the elderly, or those who are too sick to be immunised. Nanopatch polio vaccine delivers uq news the university. Nps provide an important tool for clinical application and, thus, should and can be evolved for systems that aim for various functions, such as in the case of vaccines. Jun 12, 20 kendalls research in animals shows that a 450 ng dose of an influenza vaccine was far more effective delivered through the patch than 600 ng of the same vaccine delivered via a needle. Bioengineer developing needlefree nanopatch vaccines reuters. The nanopatch has two major advantages over traditional vaccination methods. Prof mark kendall the nanopatch presents the possibility of just using a fraction of the dose compared to the needle and syringe and weve proven that in. The research programs in the center are highly synergistic among the faculty within the center and have close and.
Delivery of a polio vaccine with the nanopatch was demonstrated by uqs professor mark kendall and his research team at uqs australian. Efforts to rid the world of polio have taken another significant step. The nanopatch is just as effective as needlebased mechanisms, said. Oct 01, 20 aibns prof mark kendall is the inventor of the nanopatch, a needlefree vaccine delivery device which is under rapid research and development to product through spinout company vaxxas. Nanopatch a needlefree vaccine device wins florey medal. Kendall and his team are directly targeting these skin cells in a completely new approach to vaccination. Because less vaccine is needed for nanopatch delivery, it could make an expensive vaccine more viable to distribute in the developing world. Nanopatch polio vaccine success uq news the university of. Kendall has just returned from a feasibility study using prototypes of the nanopatch in papua new guinea, which has one of the worlds highest rates of infection with hpv a virus that can lead. Prof kendall said being both painless and needlefree, the nanopatch offers hope for those with needlephobia, as well as improving the vaccination experience for young children. Mark kendall nanopatch replacement for vaccination podcast. The nanopatch has been tested in animals on vaccines for influenza. Safe, simple and needlefree vaccinations australia unlimited. The money will enable university of queenslands professor.
View mark kendalls profile on linkedin, the worlds largest professional community. Drycoated live viral vector vaccines delivered by nanopatch. He is an entrepreneurial professor of the australian national university. The nanopatch, developed by university of queensland professor mark kendall and his bioengineering and nanotechnology team, uses 100 times less vaccine than a. An advanced platform that vaccinates by applying a patch to the skin for a few seconds. Vaxxas are working on developing the nanopatch, a needlefree vaccine delivery technology originating from prof mark kendalls laboratory within the aibn at the university of queensland. Apr 24, 2010 prof kendall said being both painless and needlefree, the nanopatch offers hope for those with needlephobia, as well as improving the vaccination experience for young children. Nanopatch vaccine breakthrough by the university of queensland.
Mark kendall at the university of queensland to work on the nanopatch a microneedle patch technology with demonstrable clinical promise. Mark kendall from the university of queensland targeting the skin for needlefree, minimally invasive delivery and diagnostics for disease. Aug 02, 2011 needleless vaccines one step closer with nanopatch. When polio vaccine backfired tainted batches killed 10. Vaccines help reduce the risk of certain illnesses by introducing dead or weakened versions of diseasecausing germs bacteria or viruses to the immune system. Engineered to directly deposit vaccine amongst dense population of key immune cells in the skin, developing an efficient and effective immune response. Nanopatch polio vaccine delivers, research indicates infection. Arc future fellow pioneers needlefree immunisation for the world. Nov 19, 2014 the nextgeneration vaccine delivery system, created by vaxxas, is called the nanopatch and is the size of an adult thumbnail. Improving the reach of vaccines to lowresource regions, with a needlefree vaccine delivery device and longterm thermostabilization author links open overlay panel xianfeng chen a 1 germain j. Image caption prof kendall has set up a company to commercialise the nanopatch the projections on the nanopatch work with the skins immune system.
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